
Temocapril HCl
CAS No. 110221-44-8
Temocapril HCl ( —— )
产品货号. M17812 CAS No. 110221-44-8
Temocapril HCl 是 Temocapril 的盐酸盐,是一种长效 ACE 抑制剂,用于治疗高血压。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥251 | 有现货 |
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10MG | ¥389 | 有现货 |
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25MG | ¥770 | 有现货 |
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50MG | ¥1199 | 有现货 |
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100MG | ¥1879 | 有现货 |
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200MG | ¥2778 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Temocapril HCl
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Temocapril HCl 是 Temocapril 的盐酸盐,是一种长效 ACE 抑制剂,用于治疗高血压。
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产品描述Temocapril HCl, the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the therapy of hypertension.(In Vitro):Temocapril hydrochloride is a prodrug of the ACE inhibitor, Temocaprilat. Temocapril hydrochloride can be readily uptaken via the small intestine, and then be converted to its active metabolite (temocaprilat) by CES1 (human carboxylesterase 1) in the liver.Temocapril hydrochloride (500 nM) reduces the inhibitory effects of RS (N-acetyltetradecapeptide renin substrate) and AngI on neurogenic vasodilation in the SHR.Temocapril hydrochloride (0.1-10 μM; 24 h) shows inductive effects on redox proteins TRX while no effect on antioxidant enzymes Cu/ZnSOD and Mn-SOD expressions.(In Vivo):Temocapril hydrochloride (10 mg/kg; p.o.; 21 d) enhances cardiomyocyte thioredoxin expression and ameliorates autoimmune myocarditis.Temocapril hydrochloride (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney.
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体外实验Temocapril hydrochloride is a prodrug of the ACE inhibitor, Temocaprilat. Temocapril hydrochloride can be readily uptaken via the small intestine, and then be converted to its active metabolite (temocaprilat) by CES1 (human carboxylesterase 1) in the liver.Temocapril hydrochloride (500 nM) reduces the inhibitory effects of RS (N-acetyltetradecapeptide renin substrate) and AngI on neurogenic vasodilation in the SHR.Temocapril hydrochloride (0.1-10 μM; 24 h) shows inductive effects on redox proteins TRX whileno effect on antioxidant enzymes Cu/ZnSOD and Mn-SOD expressions. Cell Proliferation Assay Cell Line:Cultured neonatal rat cardiomyocytes Concentration:0.1 μM, 1 μM, 10 μM Incubation Time:24 hours Result:Enhanced TRX protein expression 1.9-fold at 10 μM without affecting TRX2, Cu / Zn-SOD or Mn-SOD protein expression.
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体内实验Temocapril hydrochloride (10 mg/kg; p.o.; 21 d) enhances cardiomyocyte thioredoxin expression and ameliorates autoimmune myocarditis.Temocapril hydrochloride (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney. Animal Model:Experimental autoimmune myocarditis (EAM) rat model Dosage:10 mg/kg Administration:Oral gavage; administration by water; 21 days Result:Ameliorated EAM and prevented cellular proteins from oxidation.Enhanced cardiomyocyte redox regulatory protein TRX expression.Animal Model:Male Sprague Dawley rats Dosage:30 mg/kg Administration:Oral administration, daily, for 4 weeks Result:Suppressed the blood pressure elevation induced by Ang I.
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同义词——
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通路Others
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靶点Other Targets
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受体ACE
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研究领域Cardiovascular Disease
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适应症——
化学信息
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CAS Number110221-44-8
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分子量513.07
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分子式C23H28N2O5S2·HCl
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 100 mg/mL; 194.91 mM
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SMILESCCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CS[C@@H](CN(C1=O)CC(=O)O)c1cccs1.Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Suzuki H, Kawaratani T, Shioya H, Uji Y,Saruta T.Biopharm Drug Dispos. 1993 Jan;14(1):41-50.
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